Effect of Methanolic Extracts of Blumea Eriantha Dc Leaves on Protein Metabolism and Marker Enzymes in Streptozotocin- Induced Hyperglycemic Animals

The object of present study to investigate the possible protective effect of methanolic extracts of Blumea eriantha DC leaves on various biochemical markers in streptozotocin (STZ)-induced hyperglycemia in rats. STZ treatment (60 mg/kg/i.p) caused a hyperglycemic state that led to various physiological and biochemical alterations. Blood levels of glucose, urea, uric acid and creatinine, plasma levels of albumin and albumin/globulin ratio and the activities of diagnostic marker enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (γ -GT) in plasma, liver and kidney were markedly altered in STZ diabetic rats. Oral administration of Blumea eriantha DC (250, 500 mg/kg/p.o) for 21 days restored all these biochemical parameters to near normal levels. Thus, the present results have shown that methanolic extracts of Blumea eriantha DC leaves has the antihyperglycemic effect and consequently may alleviate liver and renal damage associated with STZinduced diabetes in rats.